Objective: To explore the best interventions and working patterns of clinical pharmacists in pediatrics and to determine the\r\neffectiveness of clinical pharmacists in pediatrics.\r\nMethods: We conducted a randomized controlled trial of 160 pediatric patients with nerve system disease, respiratory\r\nsystem disease or digestive system disease, who were randomly allocated into two groups, with 80 in each group.\r\nInterventions by clinical pharmacists in the experimental group included answering questions of physicians and nurses,\r\ngiving advice on treating patients, checking prescriptions and patient counseling at discharge. In the control group, patients\r\nwere treated without clinical pharmacist interventions.\r\nResults: Of the 109 interventions provided by clinical pharmacists during 4 months, 47 were consultations for physicians\r\nand nurses, 31 were suggestions of treatment, with 30 accepted by physicians (96.77%) and 31 were medical errors found in\r\n641 prescriptions. Five adverse drug reactions were submitted to the adverse drug reaction monitoring network, with three\r\nin the experimental group and two in the control group. The average length of stay (LOS) for patients with respiratory\r\nsystem diseases in the experimental group was 6.45 days, in comparison with 10.83 days in the control group, which was\r\nstatistically different (p value,0.05); Average drug compliance rate in the experimental group was 81.41%, in comparison\r\nwith 70.17% of the control group, which was statistically different (p value,0.05). Cost of drugs and hospitalization and rate\r\nof readmission in two weeks after discharge in the two groups were not statistically different.\r\nConclusion: Participation by clinical pharmacists in the pharmacotherapy of pediatric patients can reduce LOS of patients\r\nwith respiratory system disease and improve compliance rate through discharge education, showing no significant effects\r\non prevention of ADR, reduction of cost of drugs and hospitalization and readmission rate in two weeks.
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